Heterogeneity in distribution of amyloid-positive islets in type-2 diabetic patients

  title={Heterogeneity in distribution of amyloid-positive islets in type-2 diabetic patients},
  author={Cecilia M. Borromeo and X. Pottier and P. I. in't Veld and M. Pipeleers-Marichal and L. Kaufman and D. Pipeleers and C. F. Schravendijk},
  journal={Virchows Archiv},
  • Cecilia M. Borromeo, X. Pottier, +4 authors C. F. Schravendijk
  • Published 2004
  • Medicine, Biology
  • Virchows Archiv
  • Amyloid-containing (A+) islets are characteristic for type-2 diabetes (T2D), but their abundance seems variable among patients. It is unclear whether the distribution of A+ islets follows a certain pattern or occurs randomly throughout the pancreatic organ. We investigated the topography of A+ islets in eight pancreata of T2D patients and eight sex- and age-matched non-diabetic subjects. Transversal sections of head, body and tail segments were stained with synaptophysin combined with Congo red… CONTINUE READING
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