Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer.

@article{Archetti2015HeterogeneityFI,
  title={Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer.},
  author={Marco Archetti and Daniela Aleida Ferraro and Gerhard Christofori},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 6},
  pages={1833-8}
}
The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. Cancer cells also cooperate by sharing molecules with paracrine effects, such as growth factors, and heterogeneity can be maintained if subclones depend on each other for survival. Without strict… CONTINUE READING
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