Heterogeneity and complexity of native brain nicotinic receptors.

  title={Heterogeneity and complexity of native brain nicotinic receptors.},
  author={Cecilia Gotti and Milena Moretti and Annalisa Gaimarri and A. M. T. Zanardi and Franceso Clementi and Michele Zoli},
  journal={Biochemical pharmacology},
  volume={74 8},
Neuronal cholinergic nicotinic receptors (nAChRs) are a heterogeneous class of cationic channels that are widely distributed in the nervous system that have specific functional and pharmacological properties. They consist of homologous subunits encoded by a large multigene family, and their opening is physiologically controlled by the acetylcholine neurotransmitter or exogenous ligands such as nicotine. Their biophysical and pharmacological properties depend on their subunit composition, which… CONTINUE READING


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