Heterogeneity and Individuality: microRNAs in Mental Disorders

  title={Heterogeneity and Individuality: microRNAs in Mental Disorders},
  author={L. Hommers and K. Domschke and J. Deckert},
  journal={Journal of Neural Transmission},
  • L. Hommers, K. Domschke, J. Deckert
  • Published 2014
  • Medicine, Psychology
  • Journal of Neural Transmission
  • MicroRNAs are about 22 nucleotide long single-stranded RNA molecules, negatively regulating gene expression of a single gene or a gene network. In neural tissues, they have been implicated in developmental and neuroplasticity-related processes, such as neurogenesis, differentiation, apoptosis and long-term potentiation. Their molecular mode of action is reminiscent of findings of genome-wide association studies in mental disorders, unable to attribute the risk of disease to a specific gene, but… CONTINUE READING
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