Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes.

  title={Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes.},
  author={Ebun Aganna and Linda Hammond and Philip N. Hawkins and Anna Aldea and Shane McKee and Hans Kristian Ploos van Amstel and Claudia Mischung and Koichi Kusuhara and Frank T. Saulsbury and Helen Lachmann and Alison Bybee and Elizabeth M. McDermott and Micaela La Regina and Juan I Ar{\'o}stegui and Josep Mar{\'i} Campistol and Sharron Worthington and Kevin P. High and Michael G M Molloy and Nicholas D. Baker and Jeff L. Bidwell and Jos{\'e} Luis Casta{\~n}er and Margo Whiteford and P L Janssens-Korpola and R Manna and Richard James Powell and Patricia Woo and Pilar Sol{\'i}s and Kirsten Minden and Joost Frenkel and Jordi Yag{\"u}e and Rita M Mirakian and Graham A. Hitman and Michael F McDermott},
  journal={Arthritis and rheumatism},
  volume={48 9},
OBJECTIVE To investigate the prevalence of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among outpatients presenting with recurrent fevers and clinical features consistent with TRAPS. METHODS Mutational screening was performed in affected members of 18 families in which multiple members had symptoms compatible with TRAPS and in 176 consecutive subjects with sporadic (nonfamilial) "TRAPS-like" symptoms. Plasma concentrations of soluble tumor necrosis factor receptor… CONTINUE READING

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