Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.

@article{Ban2016HeterodyneFM,
  title={Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.},
  author={Han Y. Ban and Martin Schweiger and Venkaiah C. Kavuri and Jeffrey M. Cochran and L. Xie and David R. Busch and Jaka Katrasnik and Saurav Pathak and Stephanie Histed Chung and K. H. Lee and Regine Choe and Brian J. Czerniecki and Simon Robert Arridge and Arjun G. Yodh},
  journal={Medical physics},
  year={2016},
  volume={43 7},
  pages={
          4383
        }
}
PURPOSE The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. METHODS The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source-detector pairs (10(6)). The stand-alone clinical DOT instrument thus… 

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References

SHOWING 1-10 OF 70 REFERENCES

Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection.

An automated frequency-domain computed tomography scanner, which is more quantitative than earlier systems used in diaphanography because of the combination of intensity modulated signal detection and iterative image reconstruction.

Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging.

This tomography system provides robust, quantitative, full 3D image reconstructions with the advantages of high data throughput, single detector-tissue coupling path, and large (1L) imaging domains and it is found that point spread function measurements provide a useful and comprehensive representation of system performance.

In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography.

In vivo breast imaging with instrumentation that combines FD and CW NIR data acquisition in a single spectral reconstruction produces more accurate hemoglobin, water, and lipid results relative to FD data alone.

Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom.

We report on the nonlinear reconstruction of local absorption and fluorescence contrast in tissuelike scattering media from measured time-domain diffuse reflectance and transmittance of laser as well

Initial assessment of a simple system for frequency domain diffuse optical tomography.

Experimental tests confirmed that the system could identify and locate both scattering and absorbing inhomogeneities in a tissue-simulating phantom and accuracy of the initial estimates for the optical properties was confirmed.

Assessing the future of diffuse optical imaging technologies for breast cancer management.

The state of the art in DOI for breast cancer is outlined and a multi-institutional Network for Translational Research in Optical Imaging (NTROI) is described, which has been formed by the National Cancer Institute to advance diffuse optical spectroscopy and imaging (DOSI) for the purpose of improving breast cancer detection and clinical management.

Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography.

The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT based on large optical data sets and show good discriminatory power.

Combined optical imaging and mammography of the healthy breast: Optical contrast derived from breast structure and compression

New progress is reported in developing the instrument and software platform of a combined X-ray mammography/diffuse optical breast imaging system and a series of balloon phantom experiments and the optical image analysis of 49 healthy patients, which shows composite features from both tissue structure and pressure distribution.

Digital optical tomography system for dynamic breast imaging.

A new digital continuous-wave optical tomography system designed to simultaneously image both breasts at fast frame rates and with a large number of sources and detectors is presented.

Spatially variant regularization improves diffuse optical tomography.

A variant of Tikhonov regularization is examined in which radial variation is allowed in the value of the regularization parameter, which minimizes high-frequency noise in the reconstructed image near the source-detector locations and can produce constant image resolution and contrast across the image field.
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