Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.

@article{Moutkine2017HeterodimersOS,
  title={Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.},
  author={Imane Moutkine and Emily Quentin and Bruno P. Guiard and Luc Maroteaux and St{\'e}phane Doly},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 15},
  pages={6352-6368}
}
The serotonin receptor subtypes 2 comprise 5-HT2A, 5-HT2B, and 5-HT2C, which are Gαq-coupled receptors and display distinct pharmacological properties. Although co-expressed in some brain regions and involved in various neurological disorders, their functional interactions have not yet been studied. We report that 5-HT2 receptors can form homo- and heterodimers when expressed alone or co-expressed in transfected cells. Co-immunoprecipitation and bioluminescence resonance energy transfer studies… CONTINUE READING