Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.

@article{Levitz2016HeterodimerizationWT,
  title={Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.},
  author={Joshua Levitz and Perrine Royal and Yannick Comoglio and Brigitte Wdziekonski and S{\'e}bastien Schaub and Daniel M Clemens and Ehud Y Isacoff and Guillaume Sandoz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 15},
  pages={4194-9}
}
Twik-related K(+) channel 1 (TREK1), TREK2, and Twik-related arachidonic-acid stimulated K(+) channel (TRAAK) form the TREK subfamily of two-pore-domain K(+) (K2P) channels. Despite sharing up to 78% sequence homology and overlapping expression profiles in the nervous system, these channels show major differences in their regulation by physiological stimuli. For instance, TREK1 is inhibited by external acidification, whereas TREK2 is activated. Here, we investigated the ability of the members… CONTINUE READING
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Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel

  • SG Brohawn, J del Mármol, R MacKinnon
  • Science
  • 2012

TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation

  • DH Woo
  • Cell
  • 2012

Probing cellular protein complexes using single-molecule pulldown

  • A Jain
  • Nature
  • 2011

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