Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25.

@article{Welting2007HeterodimerizationRR,
  title={Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25.},
  author={Tim Welting and Florence M A Peters and Sanne M. M. Hensen and Nienke L van Doorn and Bastiaan J Kikkert and Jos M. H. Raats and Walther J. van Venrooij and Ger J. M. Pruijn},
  journal={RNA},
  year={2007},
  volume={13 1},
  pages={65-75}
}
Rpp20 and Rpp25 are subunits of the human RNase MRP and RNase P endoribonucleases belonging to the Alba superfamily of nucleic acid binding proteins. These proteins, which bind very strongly to each other, transiently associate with RNase MRP. Here, we show that the Rpp20-Rpp25 heterodimer is resistant to both high concentrations of salt and a nonionic detergent. The interaction of Rpp20 and Rpp25 with the P3 domain of the RNase MRP RNA appeared to be strongly enhanced by their… CONTINUE READING

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