Heterodimerization preferences of thyroid hormone receptor alpha isoforms.

  title={Heterodimerization preferences of thyroid hormone receptor alpha isoforms.},
  author={Takashi Nagaya and Yasuyuki Nomura and Masaki Fujieda and H. -A. Seo},
  journal={Biochemical and biophysical research communications},
  volume={226 2},
Thyroid hormone receptors (TRs) are members of the steroid hormone receptor superfamily and are encoded by two different genes, alpha and beta. Three isoforms (alpha 1, alpha 2, and alpha 3) are created by alternative splicing of the TR alpha gene. In TR alpha 2 and alpha 3, the distal half of the putative dimerization domain is disrupted and the carboxy terminus of the protein is substituted with different amino acids. To evaluate the properties of these alterations in the dimerization region… CONTINUE READING

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