Heterodimerization of the two major envelope proteins is essential for arterivirus infectivity.

@article{Snijder2003HeterodimerizationOT,
  title={Heterodimerization of the two major envelope proteins is essential for arterivirus infectivity.},
  author={Eric J. Snijder and Jessika C Dobbe and Willy J. M. Spaan},
  journal={Journal of virology},
  year={2003},
  volume={77 1},
  pages={97-104}
}
The two major envelope proteins of arteriviruses, the membrane protein (M) and the major glycoprotein (GP(5)), associate into a disulfide-linked heterodimer that is incorporated into the virion and has been assumed to be a prerequisite for virus assembly. Using an equine arteritis virus (EAV) infectious cDNA clone, we have analyzed the requirement for GP(5)-M heterodimerization and have identified the Cys residues involved in the formation of the GP(5)-M disulfide bond. The single Cys residue… CONTINUE READING