Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking

@article{Renner2012HeterodimerizationOS,
  title={Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking},
  author={Ute Renner and Andr{\'e} Zeug and Andrew Woehler and Marcus Niebert and Alexander E Dityatev and Galina Dityateva and Nataliya Gorinski and Daria Guseva and Dalia Abdel-Galil and Matthias Fr{\"o}hlich and Frank D{\"o}ring and Erhard Wischmeyer and Diethelm W. Richter and Erwin Neher and Evgeni G. Ponimaskin},
  journal={Journal of Cell Science},
  year={2012},
  volume={125},
  pages={2486 - 2499}
}
Serotonin receptors 5-HT1A and 5-HT7 are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established. In the present study we show that 5-HT1A and 5-HT7 receptors form heterodimers both in vitro and in vivo. Foerster resonance energy transfer-based assays revealed that, in addition to heterodimers, homodimers composed either of 5-HT1A or 5-HT7 receptors together with monomers coexist in cells. The highest affinity for complex… 

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