Heterodimerization of human apelin and kappa opioid receptors: roles in signal transduction.

@article{Li2012HeterodimerizationOH,
  title={Heterodimerization of human apelin and kappa opioid receptors: roles in signal transduction.},
  author={Yalin Li and Jing Chen and Bo Bai and Hui Du and Youwang Liu and Haiqing Liu},
  journal={Cellular signalling},
  year={2012},
  volume={24 5},
  pages={
          991-1001
        }
}
Apelin receptor (APJ) and kappa opioid receptor (KOR) are members of the family A of G protein-coupled receptors (GPCRs). These two receptors are involved in the central nervous system regulation of the cardiovascular system. Here, we explore the possibility of heterodimerization between APJ and KOR and investigate their novel signal transduction characteristics. Co-immunoprecipitation (Co-IP), co-localization and bioluminescence resonance energy transfer (BRET) assays confirmed the… CONTINUE READING
Highly Cited
This paper has 37 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.

Biochemistry and cell biology = Biochimie et biologie cellulaire • 2014
View 4 Excerpts
Highly Influenced