Heterodimerization of human apelin and kappa opioid receptors: roles in signal transduction.

  title={Heterodimerization of human apelin and kappa opioid receptors: roles in signal transduction.},
  author={Yalin Li and Jing Chen and Bo Bai and Hui Du and Youwang Liu and Haiqing Liu},
  journal={Cellular signalling},
  volume={24 5},
Apelin receptor (APJ) and kappa opioid receptor (KOR) are members of the family A of G protein-coupled receptors (GPCRs). These two receptors are involved in the central nervous system regulation of the cardiovascular system. Here, we explore the possibility of heterodimerization between APJ and KOR and investigate their novel signal transduction characteristics. Co-immunoprecipitation (Co-IP), co-localization and bioluminescence resonance energy transfer (BRET) assays confirmed the… CONTINUE READING
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The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.

Biochemistry and cell biology = Biochimie et biologie cellulaire • 2014
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