Heterodimeric neurotoxic phospholipases A2--the first proteins from venom of recently established species Vipera nikolskii: implication of venom composition in viper systematics.

@article{Ramazanova2008HeterodimericNP,
  title={Heterodimeric neurotoxic phospholipases A2--the first proteins from venom of recently established species Vipera nikolskii: implication of venom composition in viper systematics.},
  author={Anna S Ramazanova and Larisa L Zavada and Vladislav G. Starkov and Irina Kovyazina and Tatyana F Subbotina and Ekaterina E Kostyukhina and Irina N Dementieva and Tatiana V Ovchinnikova and Yuri N Utkin},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2008},
  volume={51 4},
  pages={
          524-37
        }
}
For the first time the venom of recently established viper species Vipera nikolskii was fractionated and two heterodimeric phospholipases A(2) (HDP-1 and HDP-2) were isolated. Isolation of HDP-1 and HDP-2 is the first indication of the presence of two heterodimeric phospholipases A(2) in the venom of one viper species. When tested on the frog neuromuscular junction, isolated proteins affected neuromuscular transmission acting presynaptically. Using RP-HPLC, each heterodimer was separated into… CONTINUE READING
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