Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation.

@article{Chen2004HeterodimericCO,
  title={Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation.},
  author={Yi-kai Chen and C Leng and Heidi A. Olivares and M Lee and Yuan-Chih Chang and W Kung and Shih-Chieh Ti and Yu-Hui Lo and Andrew H-J Wang and Chia-Seng Chang and Douglas K. Bishop and Y T Hsueh and Ting-Fang Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 29},
  pages={10572-7}
}
Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosisspecific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the same genetic pathway for the establishment of close juxtaposition between homologous meiotic chromosomes. Biochemical studies indicate that Hop2 and Mnd1 proteins form a stable… CONTINUE READING