Heterodimeric BMP-2/7 Antagonizes the Inhibition of All-Trans Retinoic Acid and Promotes the Osteoblastogenesis

@article{Bi2013HeterodimericBA,
  title={Heterodimeric BMP-2/7 Antagonizes the Inhibition of All-Trans Retinoic Acid and Promotes the Osteoblastogenesis},
  author={Wen-juan Bi and Zhiyuan Gu and Yuanna Zheng and Xiao Zhang and Jing Guo and Gang Wu},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Objectives Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration. The inhibitory effect of all-trans retinoic acid on osteoblastogenesis is considered to be one of the mechanisms. We hypothesized that heterodimeric bone morphogenetic protein-2/7 could antagonize all-trans retinoic acid and enhance osteoblastogenesis, with an aim to accelerate and enhance bone regeneration and implant… 
All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies
TLDR
The presence of ATRA still induced significantly higher cell viability and early differentiation than the homodimers, but ATRA significantly attenuated the advantages of BMP2/7 in inducing late and final osteoblastogenic differentiation over the hommodimers.
All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity
TLDR
Combined treatment of ATRA and BMP2/7 could be a novel approach to treat hyperactive osteoclast-induced bone loss such as in inflammation-induced severe osteoporosis and bone loss caused by cancer metastasis to bone.
The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation
TLDR
The antagonist of RARα, ER-50891 could significantly attenuate ATRA’s inhibitive effects on BMP 2-induced osteoblastogenesis.
Notoginsenoside R 1 can significantly promote in-vitro osteoblastogenesis
Notoginsenoside R1 (NGR1), one of the main effective components of Panax notoginseng, appears to be effective in promoting osteogenesis and treating osteoporosis. However, hitherto, whether NGR1 can
Notoginsenoside R1 significantly promotes in vitro osteoblastogenesis.
TLDR
Findings indicate that NGR1 significantly promotes the osteoblastogenesis of pre-osteoblasts, which suggests that N GR1 has potential for use as a bone regeneration agent.
The BMP Pathway and Its Inhibitors in the Skeleton.
TLDR
This review provides a comprehensive overview of the intricacies of the BMP pathway and its inhibitors in bone development, homeostasis, and disease and proposes two major areas of need of future study by the field: greater resolution of the gene regulatory network downstream of BMP signaling in the skeleton, and an expanded repertoire of reagents to reliably and specifically inhibit individual B MP pathway components.
Vitamin A metabolite inhibits proliferation , migration and osteogenic differentiation in a human periodontal ligament stem cells subpopulation
The periodontal ligament stem cells (PDLSCs) are regarded as the promising seed cells for in situ facilitated endogenous periodontal tissue regeneration. Nevertheless the patients with
All‐trans retinoic acid and human salivary histatin‐1 promote the spreading and osteogenic activities of pre‐osteoblasts in vitro
TLDR
It is found that co‐administration of Hst1 with ATRA additively stimulated the spreading and osteogenicity of pre‐osteoblasts on bio‐inert glass surfaces in vitro.
Erf Affects Commitment and Differentiation of Osteoprogenitor Cells in Cranial Sutures via the Retinoic Acid Pathway
TLDR
An ex vivo system for the expansion of suture-derived mesenchymal stem and progenitor cells (sdMSCs) and Transcriptome analysis indicates that Erf is required for efficient osteogenic lineage commitment of sdMSCs, and exogenous addition of retinoic acid can rescue the osteogenic differentiation defect.
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