Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.

@article{Tsuda1999HeterocyclicAM,
  title={Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.},
  author={Hitoshi Tsuda and Keiko Sekine and Norihisa Uehara and Nobuo Takasuka and Malcolm A. S. Moore and Yoshihiro Konno and K Nakashita and Masakuni Degawa},
  journal={Cancer letters},
  year={1999},
  volume={143 2},
  pages={
          229-34
        }
}
In order to elucidate whether mixed exposure to environmental carcinogens and caffeine increases the risk of cancer induction, we investigated the relationship between preneoplastic lesion development in the liver and colon and drug metabolizing enzyme induction and DNA adduct formation, in rats treated with a mixture of heterocyclic amines (HCAs) and caffeine. In Experiment 1, male F344 rats were administered 3 different HCAs, the food carcinogens, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ… CONTINUE READING
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