Heterocyclic Scaffolds in the Design of Peptidomimetic Integrin Ligands: Synthetic Strategies, Structural Aspects, and Biological Activity.

@article{Marco2016HeterocyclicSI,
  title={Heterocyclic Scaffolds in the Design of Peptidomimetic Integrin Ligands: Synthetic Strategies, Structural Aspects, and Biological Activity.},
  author={Rossella De Marco and Giacomo Mazzotti and Arianna Greco and Luca Gentilucci},
  journal={Current topics in medicinal chemistry},
  year={2016},
  volume={16 3},
  pages={
          343-59
        }
}
The integrin receptors represent valuable targets for therapeutic interventions; being overexpressed in many pathological states, their inhibition can be effective to treat a number of severe diseases. Since integrin functions are mediated by interactions with ECM protein ligands, the inhibition can be achieved by interfering with such interactions using small mimetics of the integrin-ligand recognition motifs (e.g. RGD, LDV, etc.). In this review, we focus on the antagonists with… CONTINUE READING

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