Heterocyclic Lactam Derivatives as Dual Angiotensin Converting Enzyme and Neutral Endopeptidase 24.11 Inhibitors.

@article{Stanton1994HeterocyclicLD,
  title={Heterocyclic Lactam Derivatives as Dual Angiotensin Converting Enzyme and Neutral Endopeptidase 24.11 Inhibitors.},
  author={James Lawrence Stanton and Donald Mark Sperbeck and Angelo J. Trapani and D T Cot{\'e} and Yumi Sakane and Carol Berry and R. D. Ghai},
  journal={ChemInform},
  year={1994},
  volume={25}
}
1 Citations
Section Review: Cardiovascular & Renal: Recent advances in the development of dual angiotensin-converting enzyme and neutral endopeptidase inhibitors
The development of single molecules which possess the ability to inhibit both of the membrane-bound zinc metalloproteases, angiotensin-converting enzyme EC 2.4.15.1 (ACE) and neutral endopeptidase ECExpand

References

Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors.
TLDR
A series of 13- and 14-membered ring lactam derivatives 9a,b, 10, 11, and 12a-c was prepared from L-cysteine and showed dual plasma inhibition after intravenous or oral administration. Expand