Heterochrony in limb evolution: developmental mechanisms and natural selection.

@article{Richardson2009HeterochronyIL,
  title={Heterochrony in limb evolution: developmental mechanisms and natural selection.},
  author={Michael Richardson and Sharon Mh Gobes and Anne Cornelis van Leeuwen and J Annelies E Polman and Claude Pieau and Marcelo R S{\'a}nchez-Villagra},
  journal={Journal of experimental zoology. Part B, Molecular and developmental evolution},
  year={2009},
  volume={312 6},
  pages={
          639-64
        }
}
The tetrapod limb provides several examples of heterochrony-changes in the timing of developmental events. These include species differences in the sequence of skeletal chondrogenesis, in gene transcription in the developing limbs, and in the relative time at which forelimb and hind limb buds develop. Here, we examine (i) phylogenetic trends in limb heterochrony; (ii) changes in developmental mechanisms that may lead to heterochrony; and (iii) the possible role that heterochrony plays in… CONTINUE READING
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