Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.

@article{Jong2010HeterochronicPG,
  title={Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.},
  author={Imke G. de Jong and Jan-Willem Veening and Oscar P. Kuipers},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 8},
  pages={2053-67}
}
In response to limiting nutrient sources and cell density signals, Bacillus subtilis can differentiate and form highly resistant endospores. Initiation of spore development is governed by the master regulator Spo0A, which is activated by phosphorylation via a multicomponent phosphorelay. Interestingly, only part of a clonal population will enter this developmental pathway, a phenomenon known as sporulation bistability or sporulation heterogeneity. How sporulation heterogeneity is established is… CONTINUE READING

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