Heterochromatin silencing at p53 target genes by a small viral protein

  title={Heterochromatin silencing at p53 target genes by a small viral protein},
  author={Conrado Soria and Fanny E. Estermann and Kristen C. Espantman and Clodagh C. O’Shea},
The transcription factor p53 (also known as TP53) guards against tumour and virus replication and is inactivated in almost all cancers. p53-activated transcription of target genes is thought to be synonymous with the stabilization of p53 in response to oncogenes and DNA damage. During adenovirus replication, the degradation of p53 by E1B-55k is considered essential for p53 inactivation, and is the basis for p53-selective viral cancer therapies. Here we reveal a dominant epigenetic mechanism… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
50 Citations
39 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 50 extracted citations


Publications referenced by this paper.

Similar Papers

Loading similar papers…