Heterochromatin protein 1 secures survival and transmission of malaria parasites.

@article{Brancucci2014HeterochromatinP1,
  title={Heterochromatin protein 1 secures survival and transmission of malaria parasites.},
  author={Nicolas M B Brancucci and Nicole L. Bertschi and Lei Zhu and Igor Niederwieser and Wai Hoe Chin and Rahel Wampfler and C{\'e}line Freymond and Matthias Rottmann and Ingrid Felger and Zbynek Bozdech and Till S Voss},
  journal={Cell host & microbe},
  year={2014},
  volume={16 2},
  pages={165-176}
}
Clonally variant expression of surface antigens allows the malaria parasite Plasmodium falciparum to evade immune recognition during blood stage infection and secure malaria transmission. We demonstrate that heterochromatin protein 1 (HP1), an evolutionary conserved regulator of heritable gene silencing, controls expression of numerous P. falciparum virulence genes as well as differentiation into the sexual forms that transmit to mosquitoes. Conditional depletion of P. falciparum HP1 (PfHP1… CONTINUE READING