Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner

@article{Festenstein1999HeterochromatinP1,
  title={Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner},
  author={R. Festenstein and S. Sharghi-Namini and M. Fox and K. Roderick and M. Tolaini and T. Norton and A. Saveliev and D. Kioussis and P. Singh},
  journal={Nature Genetics},
  year={1999},
  volume={23},
  pages={457-461}
}
  • R. Festenstein, S. Sharghi-Namini, +6 authors P. Singh
  • Published 1999
  • Biology, Medicine
  • Nature Genetics
  • Locus control regions (LCRs) are gene regulatory elements in mammals that can overcome the highly repressive effects normally associated with heterochromatic transgene locations (for example the centromere) in mice. Deletion of essential LCR sequences renders the cognate gene susceptible to this form of repression, so a proportion of the cells from transgenic mice that would normally express the transgene are silenced—a phenomenon known as position effect variegation (PEV). We show here that… CONTINUE READING
    Long-range control of gene expression: emerging mechanisms and disruption in disease.
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