Heterochromatin protein 1 is recruited to various types of DNA damage

  title={Heterochromatin protein 1 is recruited to various types of DNA damage},
  author={Martijn S. Luijsterburg and Christoffel Dinant and Hannes Lans and Jan Stap and Elzbieta Wiernasz and Saskia Lagerwerf and Dani{\"e}l O. Warmerdam and Michael Lindh and Maartje C. Brink and Jurek W. Dobrucki and J. A. Aten and Maria I. Fousteri and Gert Jansen and Nico P Dantuma and Wim Vermeulen and L. H. Mullenders and Adriaan B. Houtsmuller and Pernette J. Verschure and Roel van Driel},
  booktitle={The Journal of cell biology},
Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-alpha, HP1-beta, and HP1-gamma are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. This response to DNA damage requires the chromo shadow domain of HP1 and is independent of H3K9 trimethylation and proteins that detect UV damage and DSBs. Loss of HP1 results in high… CONTINUE READING
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