Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3

@article{Santenard2010HeterochromatinFI,
  title={Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3},
  author={Ang{\`e}le Santenard and C{\'e}line Ziegler-Birling and Marc Koch and L{\'a}szl{\'o} Tora and Andrew J. Bannister and Maria-Elena Torres-Padilla},
  journal={Nature Cell Biology},
  year={2010},
  volume={12},
  pages={853-862}
}
In mammals, oocyte fertilization by sperm initiates development. This is followed by epigenetic reprogramming of both parental genomes, which involves the de novo establishment of chromatin domains. In the mouse embryo, methylation of histone H3 establishes an epigenetic asymmetry and is predominant in the maternal pronucleus. However, the roles of differential incorporation of histone H3 variants in the parental chromatin, and of modified residues within specific histone variants, have not… CONTINUE READING
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