Heterochromatin formation in bistable chromatin domains controls the epigenetic repression of clonally variant Plasmodium falciparum genes linked to erythrocyte invasion.

@article{Crowley2011HeterochromatinFI,
  title={Heterochromatin formation in bistable chromatin domains controls the epigenetic repression of clonally variant Plasmodium falciparum genes linked to erythrocyte invasion.},
  author={Valerie M. Crowley and N{\'u}ria Rovira-Graells and Lluis Ribas de Pouplana and Alfred Cort{\'e}s},
  journal={Molecular microbiology},
  year={2011},
  volume={80 2},
  pages={391-406}
}
Clonally variant gene expression is a common survival strategy used by many pathogens, including the malaria parasite Plasmodium falciparum. Among the genes that show variant expression in this parasite are several members of small gene families linked to erythrocyte invasion, including the clag and eba families. The active or repressed state of these genes is clonally transmitted by epigenetic mechanisms. Here we characterized the promoters of clag3.1, clag3.2 and eba-140, and compared… CONTINUE READING