Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase

@inproceedings{Lorenz2014HeterochromatinAA,
  title={Heterochromatin assembly and transcriptome repression by Set1 in
coordination with a class II histone deacetylase},
  author={David R. Lorenz and Lauren F Meyer and Patrick J. R. Grady and Michelle M. Meyer and Hugh P Cam},
  booktitle={eLife},
  year={2014}
}
Histone modifiers play essential roles in controlling transcription and organizing eukaryotic genomes into functional domains. Here, we show that Set1, the catalytic subunit of the highly conserved Set1C/COMPASS complex responsible for histone H3K4 methylation (H3K4me), behaves as a repressor of the transcriptome largely independent of Set1C and H3K4me in… CONTINUE READING