Heterochromatin Silencing and Locus Repositioning Linked to Regulation of Virulence Genes in Plasmodium falciparum

Abstract

The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate that both a subtelomeric transgene and var genes are subject to reversible gene silencing. Var gene silencing involves the SIR complex as gene disruption of PfSIR2 results in activation of this gene family. We also demonstrate that perinuclear gene activation involves chromatin alterations and repositioning into a location that may be permissive for transcription. Together, this implies that locus repositioning and heterochromatic silencing play important roles in the epigenetic regulation of virulence genes in P. falciparum.

DOI: 10.1016/j.cell.2005.01.036

Extracted Key Phrases

6 Figures and Tables

0100200'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

1,597 Citations

Semantic Scholar estimates that this publication has 1,597 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Duraisingh2005HeterochromatinSA, title={Heterochromatin Silencing and Locus Repositioning Linked to Regulation of Virulence Genes in Plasmodium falciparum}, author={Manoj Theodore Duraisingh and Till Vo\ss and Allison J. Marty and Michael F. Duffy and R. T. Good and Jennifer K. Thompson and L{\'u}cio de Holanda Freitas-J{\'u}nior and Artur Scherf and Brendan S. Crabb and Alan F Cowman}, journal={Cell}, year={2005}, volume={121}, pages={13-24} }