Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals

  title={Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals},
  author={Ian G. Cowell and Rebecca L. Aucott and Shantha K Mahadevaiah and Paul S. Burgoyne and Neville S. Huskisson and Silvia Bongiorni and Giorgio Prantera and Laura Fanti and Sergio Pimpinelli and Rong Y Wu and David M. Gilbert and Wei W. Shi and Reinald H. Fundele and H. Boyd Morrison and P. G. Jeppesen and Prim B. Singh},
We show that methylated lysine 9 of histone H3 (Me9H3) is a marker of heterochromatin in divergent animal species. It localises to both constitutive and facultative heterochromatin and replicates late in S-phase of the cell cycle. Significantly, Me9H3 is enriched in the inactive mammalian X chromosome (Xi) in female cells, as well as in the XY body during meiosis in the male, and forms a G-band pattern along the arms of the autosomes. Me9H3 is a constituent of imprinted chromosomes that are… CONTINUE READING
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