Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.

@article{Zacheis1999HeteroarotinoidsIH,
  title={Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.},
  author={David Zacheis and Aridam Dhar and Songfeng Lu and Matora M. Madler and Josef Klucik and Chad W. Brown and Shengquan Liu and Fr{\'e}d{\'e}ric Cl{\'e}ment and Sharadha Subramanian and G M Weerasekare and Kammergericht Berlin and Michael Alan Gold and James R. Houck and Kimberly R. Fountain and Doris Mangiaracina Benbrook},
  journal={Journal of medicinal chemistry},
  year={1999},
  volume={42 21},
  pages={
          4434-45
        }
}
A class of less toxic retinoids, called heteroarotinoids, was evaluated for their molecular mechanism of growth inhibition of two head and neck squamous cell carcinoma (HNSCC) cell lines SCC-2 and SCC-38. A series of 14 heteroarotinoids were screened for growth inhibition activity in vitro. The two most active compounds, one that contained an oxygen heteroatom (6) and the other a sulfur heteroatom (16), were evaluated in a xenograph model of tumor establishment in nude mice. Five days after… CONTINUE READING
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