Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.

@article{Hayashi2008Hesr1AH,
  title={Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.},
  author={Toshinori Hayashi and Hiroki Kokubo and Byron H. Hartman and Catherine A. Ray and Thomas A. Reh and Olivia Bermingham-McDonogh},
  journal={Developmental biology},
  year={2008},
  volume={316 1},
  pages={
          87-99
        }
}
In cochlear development, the Notch signaling pathway is required for both the early prosensory phase and a later lateral inhibition phase. While it is known that Hes genes are important downstream mediators of Notch function in lateral inhibition, it is not known what genes function as mediators of the early prosensory function of Notch. We report that two members of the Hes-related gene family, Hesr1 and Hesr2, are expressed in the developing cochlea at a time and place that makes them… CONTINUE READING

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