Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats.

@article{Kamisli2015HesperidinPB,
  title={Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats.},
  author={Suat Kamisli and Osman Ciftci and Kursat Kaya and Asli Cetin and Ozden Kamişli and Cemal Ozcan},
  journal={Toxicology and industrial health},
  year={2015},
  volume={31 9},
  pages={841-51}
}
In the present study, the beneficial effect of hesperidin (HP), a citrus flavonoid, on cisplatin (CP)-induced neurotoxicity was investigated. A total of 28 rats were equally divided into four groups; the first group was kept as control. In the second and third groups, CP and HP were given at the doses of 7 and 50 mg/kg/day, respectively. In the fourth group, CP and HP were given together at the same doses. The results indicated that although CP caused significant induction of lipid… CONTINUE READING

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