Hesperidin protects against cadmium-induced pancreatitis by modulating insulin secretion, redox imbalance and iNOS/NF-ĸB signaling in rats.

@article{Aja2020HesperidinPA,
  title={Hesperidin protects against cadmium-induced pancreatitis by modulating insulin secretion, redox imbalance and iNOS/NF-ĸB signaling in rats.},
  author={P. M. Aja and F. I. Izekwe and A. Famurewa and E. U. Ekpono and F. Nwite and I. O. Igwenyi and J. Awoke and O. G. Ani and C. Aloke and N. Obasi and Kester U Udeh and B. A. Ale},
  journal={Life sciences},
  year={2020},
  pages={
          118268
        }
}
AIM Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidative stress-mediated inflammation and pancreatitis in Wistar rats. MAIN METHODS Forty (40) rats randomly assigned to 5 groups (n = 8) were administered normal saline or hesperidin… Expand
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