Hesperidin inhibits insulin-induced phosphoinositide 3–kinase/Akt activation in human pre-B cell line NALM-6

@article{Shahbazi2018HesperidinII,
  title={Hesperidin inhibits insulin-induced phosphoinositide 3–kinase/Akt activation in human pre-B cell line NALM-6},
  author={R. Shahbazi and Makan Cheraghpour and Reza Homayounfar and M. Nazari and J. Nasrollahzadeh and Sayed Hossein Davoodi},
  journal={Journal of Cancer Research and Therapeutics},
  year={2018},
  volume={14},
  pages={503 - 508}
}
Context: It has been shown that hesperidin induces apoptosis in NALM-6 cells through inhibition of nuclear factor-kappa B (NF-κB) activation. Aims: To investigate the effect of hesperidin on inhibition of NF-κB activation through blocking phosphoinositide 3–kinase (PI3K)/Akt pathway as a main target in cancer treatment, in NALM-6 cells. Materials and Methods: NALM-6 cells were incubated with two concentrations of hesperidin (25, 50 μM) in the presence or absence of insulin (100 nM), as a potent… Expand
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