Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance.

@article{Arafa2009HesperidinAB,
  title={Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance.},
  author={Hossam M. M. Arafa and Hamdy A A Aly and Mohamed Fahmy Abd-Ellah and Hazem El-Refaey},
  journal={Toxicology and industrial health},
  year={2009},
  volume={25 6},
  pages={417-27}
}
Benzo[alpha]pyrene (BaP) is one of the polycyclic aromatic hydrocarbons, which has shown carcinogenic, teratogenic, and mutagenic potentials. The reproductive toxicity of BaP in male was not well investigated. Thereby, we have addressed in the current study the testicular toxicity of BaP and the postulate whether or not the citrus flavonoid, hesperidin (HDN), could ameliorate such toxicity in male Swiss albino rats. In this sense, animals were challenged with BaP (50 mg/kg/day, orally) for 10… CONTINUE READING

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Hesperidin attenuates benzo[alpha ] pyrene - induced testicular toxicity in rats via regulation of oxidant / antioxidant balance .
Prior administration of HDN ahead of BaP challenge ameliorated all the histological and biochemical alterations induced by BaP. It improved the epididymal function and mitigated the injurious effects of BaP on the seminiferous tubules .
Prior administration of HDN ahead of BaP challenge ameliorated all the histological and biochemical alterations induced by BaP. It improved the epididymal function and mitigated the injurious effects of BaP on the seminiferous tubules .
Thereby , we have addressed in the current study the testicular toxicity of BaP and the postulate whether or not the citrus flavonoid , hesperidin ( HDN ) , could ameliorate such toxicity in male Swiss albino rats .
It also markedly deteriorated epididymal function as shown by decreased sperm count , motility , and daily sperm production .
SpermatocytesAnatomic structure is physical part ofSeminiferous tubule structure
It decreased the relative testis weight and induced pyknosis and necrobiotic changes as well as chromatolysis in the nuclei of the spermatocytes in the seminiferous tubules .
Hesperidin attenuates benzo[alpha ] pyrene - induced testicular toxicity in rats via regulation of oxidant / antioxidant balance .
Thereby , we have addressed in the current study the testicular toxicity of BaP and the postulate whether or not the citrus flavonoid , hesperidin ( HDN ) , could ameliorate such toxicity in male Swiss albino rats .
It also markedly deteriorated epididymal function as shown by decreased sperm count , motility , and daily sperm production .
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