Hesperidin as a preventive resistance agent in MCF-7 breast cancer cells line resistance to doxorubicin.

@article{Febriansah2014HesperidinAA,
  title={Hesperidin as a preventive resistance agent in MCF-7 breast cancer cells line resistance to doxorubicin.},
  author={Rifki Febriansah and D. P. Putri and Sarmoko and N. A. Nurulita and E. Meiyanto and A. Nugroho},
  journal={Asian Pacific journal of tropical biomedicine},
  year={2014},
  volume={4 3},
  pages={
          228-33
        }
}
OBJECTIVE To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin. METHODS The cytotoxic properties, 50% inhibition concentration (IC50) and its combination with doxorubicin in MCF-7 cell lines resistant to doxorubicin (MCF-7/Dox) cells were determined using MTT assay. Apoptosis induction was examined by double staining assay using ethidium… Expand
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