Corpus ID: 18940732

Hesperidin as a Promising Anti-Diabetic Flavonoid: the Underlying Molecular Mechanism

@inproceedings{Mahmoud2016HesperidinAA,
  title={Hesperidin as a Promising Anti-Diabetic Flavonoid: the Underlying Molecular Mechanism},
  author={A. Mahmoud and Omnia E. Hussein and Ommega Internationals},
  year={2016}
}
Diabetes mellitus is a worldwide metabolic disorder with a rapidly increasing incidence. The International Diabetes Federation (IDF) has estimated the number of patients with diabetes to be 415 million in 2015. The IDF also expected that the number of diabetic patients will increase to 642 million by 2040[1]. The currently used therapeutic options for the management of diabetes has their own limitations. Therefore, there is a greater need for safe and effective alternative anti-diabetic agents… Expand
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It is suggested that hesperidin may improve TAC and alleviate serum froctoseamin, 8‐OHDG, and MDA levels in type 2 diabetes. Expand
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References

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In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
TLDR
Results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced type 2 diabetic rats. Expand
Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions
TLDR
In combination with insulin, hesperidin not only attenuated the diabetic condition but also reversed neuropathic pain via control over hyperglycemia as well as hyperlipidemia to down-regulate generation of free radical, release of pro-inflammatory cytokines aswell as elevation in membrane bound enzyme. Expand
Hematological alterations in diabetic rats - Role of adipocytokines and effect of citrus flavonoids
TLDR
It is indicated that hesperidin and naringin exert protection to diabetes-associated anemia in type 2 diabetic rats that could be due to attenuation of proinflammatory cytokine production and stimulation of adiponectin expression. Expand
Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes
TLDR
It is demonstrated that hesperidin exhibits potent antioxidant and neuroprotective effects on the brain tissue against the diabetic oxidative damage in STZ-induced rodent model and significantly attenuated the altered levels of oxidative stress and neurotoxicity biomarkers. Expand
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TLDR
The present findings show the protective role of rutin against lipid peroxidation and suggest that r Rutin possesses antioxidant potential that may be used for therapeutic purposes. Expand
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TLDR
The present study provides the first clarification of the detailed antioxidant SARs of T. resupinatum flavonoids and points to the involvement of Nrf2 in their hepatoprotective activity. Expand
Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats.
TLDR
Results showed that hesperidin and naringin have potential antihyperglycemic and antidyslipidemic efficacies as well as cardiac function improving action in HFD/STZ-induced type 2 diabetic rats. Expand
Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice.
TLDR
The current results suggest that hesperidin and naringin are beneficial for improving hyperlipidemia and hyperglycemia in type-2 diabetic animals by partly regulating the fatty acid and cholesterol metabolism and affecting the gene expression of glucose-regulating enzymes. Expand
Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats.
TLDR
Preliminary experimental findings demonstrate that both hesperidin and naringin exhibit antidiabetic effects in a rat model of T2DM by potentiating the antioxidant defense system and suppressing proinflammatory cytokine production. Expand
Hesperidin Produces Cardioprotective Activity via PPAR-γ Pathway in Ischemic Heart Disease Model in Diabetic Rats
TLDR
Hesperidin pretreatment significantly improved mean arterial pressure, reduced left ventricular end-diastolic pressure, and improved both inotropic and lusitropic function of the heart as compared to IR-control, and PPAR-γ pathway involvement in the cardioprotective activity of hesperidins in I/R model in rats is evidence for the first time. Expand
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