Corpus ID: 18940732

Hesperidin as a Promising Anti-Diabetic Flavonoid: the Underlying Molecular Mechanism

  title={Hesperidin as a Promising Anti-Diabetic Flavonoid: the Underlying Molecular Mechanism},
  author={A. Mahmoud and Omnia E. Hussein and Ommega Internationals},
Diabetes mellitus is a worldwide metabolic disorder with a rapidly increasing incidence. The International Diabetes Federation (IDF) has estimated the number of patients with diabetes to be 415 million in 2015. The IDF also expected that the number of diabetic patients will increase to 642 million by 2040[1]. The currently used therapeutic options for the management of diabetes has their own limitations. Therefore, there is a greater need for safe and effective alternative anti-diabetic agents… Expand
Evaluation of Antioxidant and α-glucosidase Inhibitory Activities of Codonopsisjavanica (Blume) Hook. f. Thoms’ Root Extract
This study aims to evaluate the antioxidant ability and α-glucosidase inhibitory activities of Codonopsisjavanica extract to elucidate its mechanism in the treatment of diabetes type 2. The roots ofExpand
Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial
It is suggested that hesperidin may improve TAC and alleviate serum froctoseamin, 8‐OHDG, and MDA levels in type 2 diabetes. Expand
Hesperidin ameliorates insulin resistance by regulating the IRS1‐GLUT2 pathway via TLR4 in HepG2 cells
It is demonstrated that HES decreased the levels of TNF‐α and IL‐6, attenuated the glucose content in culture medium and increased glucose uptake in insulin‐resistant HepG2 cells in vitro. Expand
The traditional Chinese medication nuanxin capsule aids in the treatment of chronic heart failure
Treatment with Nuanxin capsule significantly decreased mortality and rehospitalization rate and had favorable effects on secondary outcomes, and Fail-safe value for NYHA functional classification showed negligible publication bias. Expand
Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea.
  • G. Zengin, R. Ceylan, +9 authors M. F. Mahomoodally
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2017
MA and MC were found to be rich in phytochemicals with potent antioxidant, antimicrobial, and antigenotoxic activities that can be further studied for the management of neurodegenerative complications, diabetes, and hyperpigmentation. Expand


In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
Results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced type 2 diabetic rats. Expand
Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions
In combination with insulin, hesperidin not only attenuated the diabetic condition but also reversed neuropathic pain via control over hyperglycemia as well as hyperlipidemia to down-regulate generation of free radical, release of pro-inflammatory cytokines aswell as elevation in membrane bound enzyme. Expand
Hematological alterations in diabetic rats - Role of adipocytokines and effect of citrus flavonoids
It is indicated that hesperidin and naringin exert protection to diabetes-associated anemia in type 2 diabetic rats that could be due to attenuation of proinflammatory cytokine production and stimulation of adiponectin expression. Expand
Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes
It is demonstrated that hesperidin exhibits potent antioxidant and neuroprotective effects on the brain tissue against the diabetic oxidative damage in STZ-induced rodent model and significantly attenuated the altered levels of oxidative stress and neurotoxicity biomarkers. Expand
Influence of rutin on biochemical alterations in hyperammonemia in rats.
  • A. Mahmoud
  • Chemistry, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2012
The present findings show the protective role of rutin against lipid peroxidation and suggest that r Rutin possesses antioxidant potential that may be used for therapeutic purposes. Expand
A phytochemical and computational study on flavonoids isolated from Trifolium resupinatum L. and their novel hepatoprotective activity.
The present study provides the first clarification of the detailed antioxidant SARs of T. resupinatum flavonoids and points to the involvement of Nrf2 in their hepatoprotective activity. Expand
Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats.
Results showed that hesperidin and naringin have potential antihyperglycemic and antidyslipidemic efficacies as well as cardiac function improving action in HFD/STZ-induced type 2 diabetic rats. Expand
Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice.
The current results suggest that hesperidin and naringin are beneficial for improving hyperlipidemia and hyperglycemia in type-2 diabetic animals by partly regulating the fatty acid and cholesterol metabolism and affecting the gene expression of glucose-regulating enzymes. Expand
Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats.
Preliminary experimental findings demonstrate that both hesperidin and naringin exhibit antidiabetic effects in a rat model of T2DM by potentiating the antioxidant defense system and suppressing proinflammatory cytokine production. Expand
Hesperidin Produces Cardioprotective Activity via PPAR-γ Pathway in Ischemic Heart Disease Model in Diabetic Rats
Hesperidin pretreatment significantly improved mean arterial pressure, reduced left ventricular end-diastolic pressure, and improved both inotropic and lusitropic function of the heart as compared to IR-control, and PPAR-γ pathway involvement in the cardioprotective activity of hesperidins in I/R model in rats is evidence for the first time. Expand