Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice.

Abstract

In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100 mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction. Further immunohistochemical analysis showed significantly attenuated β-amyloid deposition, plaque associated APP expression, microglial activation and TGF-β immunoreactivity in brains of APP/PS1 mice, which suggests that ameliorated behavioral impairments might be attributable to reduced Aβ deposition and attenuated neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects of hesperidin were confirmed in vitro. Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases.

DOI: 10.1016/j.bbr.2014.12.012

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@article{Li2015HesperidinAB, title={Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice.}, author={Chaoyun Li and Caroline Zug and Hongchun Qu and Hermann Josef Schluesener and Zhiyuan Zhang}, journal={Behavioural brain research}, year={2015}, volume={281}, pages={32-42} }