Corpus ID: 22570574

Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats.

@article{AbdelRaheem2009HesperidinAD,
  title={Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats.},
  author={I. T. Abdel-Raheem and Ahmed A. Abdel-ghany},
  journal={Journal of the Egyptian National Cancer Institute},
  year={2009},
  volume={21 2},
  pages={
          175-84
        }
}
BACKGROUND Doxorubicin (DOX) is a potent chemotherapeutic agent used in the treatment of several tumors but its cardiac toxicity prevents its use at a maximum dose, representing an important problem. Increased reactive oxygen species (ROS) and imbalance in nitric oxide (NO) production have been implicated in the cardiotoxicity of doxorubicin. Hesperidin is a citrus bioflavonoid that possesses a potent antioxidant and NO modulating activities. OBJECTIVES Therefore, the aim of this study was to… Expand
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ROLE OF FLAVONOIDS AGAINST ADRIAMYCIN TOXICITY.
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