Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells

@inproceedings{Lee2012HesperidinIA,
  title={Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells},
  author={Kyung-Ae Lee and Sang Han Lee and Yong-Jin Lee and Seung Mi Baeg and Jung-Hyun Shim},
  booktitle={Biomolecules & therapeutics},
  year={2012}
}
Hesperidin, a flavanone present in citrus fruits, has been studied as potential therapeutic agents that have anti-tumor activity and apoptotic effects in several cancers, but there is no report about the apoptotic effect of hesperidin in human malignant pleural mesothelioma through the specificity protein 1 (Sp1) protein. We investigated whether hesperidin inhibited cell growth and regulated Sp1 target proteins by suppressing the levels of Sp1 protein in MSTO-211H cells. The IC50 value of… CONTINUE READING

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The IC50 value of hesperidin was determined to be 152.3 μM in MSTO-211H cells for 48 h. Our results suggested that hesperidin ( 0 - 160 μM ) decreased cell viability , and induced apoptotic cell death .
The IC50 value of hesperidin was determined to be 152.3 μM in MSTO-211H cells for 48 h. Our results suggested that hesperidin ( 0 - 160 μM ) decreased cell viability , and induced apoptotic cell death .
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