Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta‐analysis of randomized controlled clinical trials
@article{Mohammadi2019HesperidinAM, title={Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta‐analysis of randomized controlled clinical trials}, author={Mohammad Reza Mohammadi and Nahid Ramezani-Jolfaie and Elnaz Lorzadeh and Yadollah Khoshbakht and Amin Salehi-abargouei}, journal={Phytotherapy Research}, year={2019}, volume={33}, pages={534 - 545} }
Previous studies have led to conflicting results regarding the effect of hesperidin supplementation on cardiometabolic markers. This study aimed to evaluate the efficacy of hesperidin supplementation on lipid profile and blood pressure through a systematic review and meta‐analysis of randomized controlled trials (RCTs). PubMed, Web of Science, Scopus, and Google Scholar, as well as the reference lists of the identified relevant RCTs, were searched up to May 2018. Effect sizes were pooled by…
17 Citations
The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials.
- Medicine, BiologyChemico-biological interactions
- 2019
Effects of orange juice intake on cardiovascular risk factors: A systematic review and meta‐analysis of randomized controlled clinical trials
- Medicine, BiologyPhytotherapy research : PTR
- 2021
It is suggested that the intake of OJ might be associated with improved serum total cholesterol and insulin sensitivity, and due to low‐to‐moderate quality of meta‐evidence, the results must be interpreted with caution.
Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials
- Medicine, BiologyPhytotherapy research : PTR
- 2021
An umbrella review of the association of phytonutrient supplements (PNSs) with biomarkers of cardiovascular disease provided up‐to‐date evidence for the effect of PNSs on biomarkers related to hypertension, dyslipidemia, and diabetes.
The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis.
- BiologyComplementary therapies in medicine
- 2020
Impact of hesperidin in 100% orange juice on chronic disease biomarkers: A narrative systematic review and gap analysis.
- MedicineCritical reviews in food science and nutrition
- 2021
A review revealed a trend toward improving chronic disease biomarkers following consumption of hesperidin in 100% orange juice, which made the role of hes peridinIn 100% OJ on chronic diseases unclear.
The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
- MedicineEuropean Journal of Nutrition
- 2019
It is shown that hesperidin supplementation can improve metabolic abnormalities and inflammatory status in patients with MetS and in control group only glucose and insulin significantly decreased.
Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability
- BiologyNutrients
- 2020
Hemperidin’s beneficial effects on CVD risk factors are focused on, paying special attention to the high interindividual variability in response to hesperidIn-based acute and chronic interventions, which can be partly attributed to differences in gut microbiota.
A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial.
- MedicineClinical nutrition
- 2020
The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial
- MedicineEuropean Journal of Clinical Nutrition
- 2020
This study confirmed that hesperidin and flaxseed supplementation improved glucose and lipid metabolism, while reduced inflammation and hepatic steatosis (controlled attenuation parameter) in NAFLD patients.
The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action
- MedicineNutrients
- 2022
The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and…
References
SHOWING 1-10 OF 106 REFERENCES
Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
- MedicineJournal of the American Heart Association
- 2016
The results of the meta‐analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day.
Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials
- MedicineCritical reviews in food science and nutrition
- 2017
Available evidence from RCTs does not suggest any clinically relevant effect of quercetin supplementation on plasma lipids, apart from a significant reduction of triglycerides at doses above 50 mg/day.
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials.
- MedicineThe American journal of clinical nutrition
- 2008
The effects of flavonoids from soy and cocoa have been the main focus of attention and future studies should focus on other commonly consumed subclasses, examine dose-response effects, and be of long enough duration to allow assessment of clinically relevant endpoints.
A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels.
- BiologyClinical nutrition
- 2014
Effect of resveratrol on lipid profile: An updated systematic review and meta‐analysis on randomized clinical trials
- BiologyPharmacological research
- 2018
Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men.
- MedicineClinical nutrition
- 2015
Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals.
- MedicineThe American journal of clinical nutrition
- 2016
The cardiovascular health benefits of hesperidin 2S in overweight and obese individuals with a relatively healthy endothelium are indicated, and there was a tendency toward a reduction of adhesion molecules and a decrease in SBP and DBP.
Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.
- MedicineThe American journal of clinical nutrition
- 2011
In healthy, middle-aged, moderately overweight men, orange juice decreases DBP when regularly consumed and postprandially increases endothelium-dependent microvascular reactivity, suggesting that hesperidin could be causally linked to the beneficial effect of orange juice.
Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review
- MedicineObesity reviews : an official journal of the International Association for the Study of Obesity
- 2016
Dietaries rich in polyphenols, such as the Mediterranean diet, which promote the consumption of diverse polyphenol‐rich products could be an effective nutritional strategy to improve the health of patients with MetS.
Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial
- MedicinePhytotherapy research : PTR
- 2017
It is suggested that hesperidin may improve TAC and alleviate serum froctoseamin, 8‐OHDG, and MDA levels in type 2 diabetes.