Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta‐analysis of randomized controlled clinical trials

  title={Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta‐analysis of randomized controlled clinical trials},
  author={Mohammad Reza Mohammadi and Nahid Ramezani-Jolfaie and Elnaz Lorzadeh and Yadollah Khoshbakht and Amin Salehi-Abargouei},
  journal={Phytotherapy Research},
  pages={534 - 545}
Previous studies have led to conflicting results regarding the effect of hesperidin supplementation on cardiometabolic markers. This study aimed to evaluate the efficacy of hesperidin supplementation on lipid profile and blood pressure through a systematic review and meta‐analysis of randomized controlled trials (RCTs). PubMed, Web of Science, Scopus, and Google Scholar, as well as the reference lists of the identified relevant RCTs, were searched up to May 2018. Effect sizes were pooled by… 
Effects of orange juice intake on cardiovascular risk factors: A systematic review and meta‐analysis of randomized controlled clinical trials
It is suggested that the intake of OJ might be associated with improved serum total cholesterol and insulin sensitivity, and due to low‐to‐moderate quality of meta‐evidence, the results must be interpreted with caution.
Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials
An umbrella review of the association of phytonutrient supplements (PNSs) with biomarkers of cardiovascular disease provided up‐to‐date evidence for the effect of PNSs on biomarkers related to hypertension, dyslipidemia, and diabetes.
Impact of hesperidin in 100% orange juice on chronic disease biomarkers: A narrative systematic review and gap analysis.
A review revealed a trend toward improving chronic disease biomarkers following consumption of hesperidin in 100% orange juice, which made the role of hes peridinIn 100% OJ on chronic diseases unclear.
The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
It is shown that hesperidin supplementation can improve metabolic abnormalities and inflammatory status in patients with MetS and in control group only glucose and insulin significantly decreased.
Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability
Hemperidin’s beneficial effects on CVD risk factors are focused on, paying special attention to the high interindividual variability in response to hesperidIn-based acute and chronic interventions, which can be partly attributed to differences in gut microbiota.
The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial
This study confirmed that hesperidin and flaxseed supplementation improved glucose and lipid metabolism, while reduced inflammation and hepatic steatosis (controlled attenuation parameter) in NAFLD patients.
The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action
The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and


Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
The results of the meta‐analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day.
Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials
  • A. Sahebkar
  • Medicine
    Critical reviews in food science and nutrition
  • 2017
Available evidence from RCTs does not suggest any clinically relevant effect of quercetin supplementation on plasma lipids, apart from a significant reduction of triglycerides at doses above 50 mg/day.
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials.
The effects of flavonoids from soy and cocoa have been the main focus of attention and future studies should focus on other commonly consumed subclasses, examine dose-response effects, and be of long enough duration to allow assessment of clinically relevant endpoints.
Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals.
The cardiovascular health benefits of hesperidin 2S in overweight and obese individuals with a relatively healthy endothelium are indicated, and there was a tendency toward a reduction of adhesion molecules and a decrease in SBP and DBP.
Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.
In healthy, middle-aged, moderately overweight men, orange juice decreases DBP when regularly consumed and postprandially increases endothelium-dependent microvascular reactivity, suggesting that hesperidin could be causally linked to the beneficial effect of orange juice.
Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review
  • M. Amiot, C. Riva, A. Vinet
  • Medicine
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2016
Dietaries rich in polyphenols, such as the Mediterranean diet, which promote the consumption of diverse polyphenol‐rich products could be an effective nutritional strategy to improve the health of patients with MetS.
Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial
It is suggested that hesperidin may improve TAC and alleviate serum froctoseamin, 8‐OHDG, and MDA levels in type 2 diabetes.