Hes6 regulates myogenic differentiation.

  title={Hes6 regulates myogenic differentiation.},
  author={Judy A. Cossins and Ann E. Vernon and Yun Zhang and Anna Philpott and Philip H Jones},
  volume={129 9},
Hes6 is a basic helix-loop-helix transcription factor homologous to Drosophila Enhancer of Split (EoS) proteins. It is known to promote neural differentiation and to bind to Hes1, a related protein that is part of the Notch signalling pathway, affecting Hes1-regulated transcription. We show that Hes6 is expressed in the murine embryonic myotome and is induced on C2C12 myoblast differentiation in vitro. Hes6 binds DNA containing the Enhancer of Split E box (ESE) motif, the preferred binding site… CONTINUE READING