Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.

@article{Wendorff2010Hes1IA,
  title={Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.},
  author={Agnieszka Anna Wendorff and Ute Koch and F Thomas Wunderlich and Silvia Wirth and Christelle Dubey and Jens C. Br{\"u}ning and Hugh R. N. Macdonald and Freddy Radtke},
  journal={Immunity},
  year={2010},
  volume={33 5},
  pages={
          671-84
        }
}
Although canonical Notch signaling regulates multiple hematopoietic lineage decisions including T cell and marginal zone B cell fate specification, the downstream molecular mediators of Notch function are largely unknown. We showed here that conditional inactivation of Hes1, a well-characterized Notch target gene, in adult murine bone marrow (BM) cells severely impaired T cell development without affecting other Notch-dependent hematopoietic lineages such as marginal zone B cells. Competitive… CONTINUE READING
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