Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1.

Abstract

A transcriptional regulator, Hes1, plays crucial roles in the control of differentiation and proliferation of neuronal, endocrine, and T-lymphocyte progenitors during development. Mechanisms for the regulation of cell proliferation by Hes1, however, remain to be verified. In embryonic carcinoma cells, endogenous Hes1 expression was repressed by retinoic… (More)

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@article{Murata2005Hes1DC, title={Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1.}, author={Kaoru Murata and Masakazu Hattori and Norihito Hirai and Yoriko Shinozuka and Hiromi Hirata and Ryoichiro Kageyama and Toshiyuki Sakai and Nagahiro Minato}, journal={Molecular and cellular biology}, year={2005}, volume={25 10}, pages={4262-71} }