Herpesviruses in periodontal diseases.

  title={Herpesviruses in periodontal diseases.},
  author={J{\o}rgen Slots},
  journal={Periodontology 2000},
  • J. Slots
  • Published 1 June 2005
  • Law
  • Periodontology 2000
...If, as is sometimes supposed, science consisted in nothing but the laborious accumulation of facts, it would soon come to a standstill, crushed, as it were, under its own weight...The suggestion of a new idea, or the detection of a law, supersedes much that has previously been a burden on the memory, and by introducing order and coherence facilitates the retention of the remainder in an available form... Lord Rayleigh, University of Cambridge, 1884. 
Herpesviruses and Periodontal Disease: A Cautionary Tale
This paper critically analyzes data in the light of consolidated knowledge that was developed in the characterization of virus-bacteria cooperative interactions, and proposes new topics of investigation to clarify the role of herpesviral infections in periodontitis and their potential predictive role as markers of progression.
Are viruses just the bystanders for Periodontal diseases?: A review
The purpose of this review is to evaluate the evidence supporting the viral hypothesis of periodontal eitopathogenesis and suggest viruses probably might not act as primary periodontopathic agents but they might cooperate the specific bacteria inperiodontal disease progression.
Combating Novel COVID-19: Guidelines for the Periodontal Practitioner
The field of Dentistry is always a source of high-risk infectious material generation owing to its professional nature and the recent pandemic spread of novel corona virus infectious disease is alarming the community.
Chronic Periodontitis and Herpes Viruses
The role of the herpes viruses in the development of chronic periodontitis is discussed, which is prevalent in adults, but can be observed in children, and has a slow to moderate rate of disease progression.
Periodontology: past, present, perspectives.
  • J. Slots
  • Medicine, Biology
    Periodontology 2000
  • 2013
This volume of Periodontology 2000 covers key subdisciplines of periodontology, ranging from etiopathogeny to therapy, with emphasis on diagnosis, classification, epidemiology, risk factors, microbiology, immunology, systemic complications, anti-infective therapy, reparative treatment, self-care and affordability issues.
The aim of the present review is to provide a critical evaluation of the role of viruses in periodontal etiopathogenesis and their future clinical implications might revolutionize existing strategies to diagnose, prevent, and treat the disease.
Noma (cancrum oris): An unresolved global challenge
Noma is a mutilating necrotizing disease of uncertain etiology that most frequently affects children, particularly in sub‐Saharan Africa, who are malnourished or debilitated by systemic conditions including but not limited to malaria, measles, and tuberculosis.
Human herpes virus: Bacteria and periodontium
This review discusses the human herpes viruses, their effect on periodontium, interaction with bacteria, various diagnostic method and therapeutic implication, and how these viruses cooperate with specific bacteria in periodontal tissue breakdown may constitute a major cause of progression of destructive periodontitis.
Viruses, periodontitis, and comorbidities.
The current knowledge of the role of viruses in connecting periodontal diseases and systemic conditions is examined and the mechanistic basis for such connections is delve into and highlight the importance of those relationships in the management and treatment of patients.


Stalemating a clever opportunist: lessons from murine cytomegalovirus.
Cytomegalovirus infection and atherosclerosis.
Evidence is provided that in immunosuppressed heart transplant patients infected with CMV, atherosclerosis is prone to develop in the transplanted heart and this provides an important basis for further investigation of the role of CMV in atherogenesis.
The human cytomegalovirus.
Virus self-improvement through inflammation: No pain, no gain
  • E. Mocarski
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
The work reported in this issue of PNAS shows that prostaglandin E2, a key mediator in the inflammatory response, is induced and performs an important function to support viral replication.
Pathogenesis of cancrum oris (noma): confounding interactions of malnutrition with infection.
It is postulate, subject to additional studies, that evolution of the oral mucosal ulcers including acute necrotizing gingivitis to noma is triggered by a consortium of microorganisms of which Fusobacterium necrophorum is a key component.
Cytomegalovirus-induced osteomyelitis in a patient with the acquired immunodeficiency syndrome.
Osteomyelitis should be added to the list of infections caused by CMV in patients with AIDS.
Detection of herpes simplex virus in gingival tissue.
Findings of viral genome and protein expression suggest that the herpes simplex virus is present in the latent form in the gingiva.
The pathogenicity of cytomegalovirus.
  • C. Sweet
  • Biology, Medicine
    FEMS microbiology reviews
  • 1999
Current information on the role of cytomegalovirus genes in tissue tropism, immune evasion, latency, reactivation from latency and damage is described.
Noma: an "infectious" disease of unknown aetiology.
Casual or Causal Relationship between Periodontal Infection and Non-oral Disease?
  • J. Slots
  • Medicine
    Journal of dental research
  • 1998
Dental focal infection must be assumed in other types of infectious heart disease, intracranial infections, thoracic infections, and various medical infections that contain organisms indigenous to the oral cavity, indicating the relative risk of acquiring coronary heart disease from periodontal disease is low.