Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2

@article{Howell2004HerpesvirusPE,
  title={Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2},
  author={Melanie Howell and Tracey Williams and Sheila A Hazlewood},
  journal={BMC Microbiology},
  year={2004},
  volume={5},
  pages={6 - 6}
}
Epstein-Barr virus (EBV) latently infects about 90% of the human population and is associated with benign and malignant diseases of lymphoid and epithelial origin. BHRF1, an early lytic cycle antigen, is an apoptosis suppressing member of the Bcl-2 family. In vitro studies imply that BHRF1 is dispensable for both virus replication and transformation. However, the fact that BHRF1 is highly conserved not only in all EBV isolates studied to date but also in the analogous viruses Herpesvirus papio… CONTINUE READING
3 Citations
35 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Bellows DS: Virus versus cellular BCL-2 proteins

  • JM Hardwick
  • Cell Death Diff 2003,
  • 2003
1 Excerpt

Host-microbe interactions:viruses Viral strategies for breaching host defences: tipping the balance towards survival

  • F Tufaro
  • Curr Opin in Microbiol
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…