Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.

Abstract

Erythropoiesis, the production of red blood cells, must be tightly controlled to ensure adequate oxygen delivery to tissues without causing thrombosis or stroke. Control of physiologic and pathologic erythropoiesis is dependent predominantly on erythropoietin (EPO), the expression of which is regulated by hypoxia-inducible factor (HIF) activity in response… (More)
DOI: 10.1172/JCI57332

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