Herpesvirus Genome Integration into Telomeric Repeats of Host Cell Chromosomes.

  title={Herpesvirus Genome Integration into Telomeric Repeats of Host Cell Chromosomes.},
  author={Nikolaus Osterrieder and Nina Wallaschek and Benedikt B Kaufer},
  journal={Annual review of virology},
  volume={1 1},
It is well known that numerous viruses integrate their genetic material into host cell chromosomes. Human herpesvirus 6 (HHV-6) and oncogenic Marek's disease virus (MDV) have been shown to integrate their genomes into host telomeres of latently infected cells. This is unusual for herpesviruses as most maintain their genomes as circular episomes during the quiescent stage of infection. The genomic DNA of HHV-6, MDV, and several other herpesviruses harbors telomeric repeats (TMRs) that are… CONTINUE READING
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