Herpesviral protein networks and their interaction with the human proteome.

  title={Herpesviral protein networks and their interaction with the human proteome.},
  author={Peter Uetz and Yu-An Dong and Christine Zeretzke and Christine Atzler and Armin Baiker and Bonnie Berger and Seesandra V. Rajagopala and Maria Roupelieva and Dietlind Rose and Even Fossum and Juergen Haas},
  volume={311 5758},
The comprehensive yeast two-hybrid analysis of intraviral protein interactions in two members of the herpesvirus family, Kaposi sarcoma-associated herpesvirus (KSHV) and varicella-zoster virus (VZV), revealed 123 and 173 interactions, respectively. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to… CONTINUE READING
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